LY96 antibody (AA 2-160)

Catalog No. ABIN1885505

Product Details anti-LY96 Antibody

Target: LY96 (Lymphocyte Antigen 96 (LY96))

Binding Specificity: AA 2-160

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This LY96 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Immunoaffinity chromotography purified IgG

Immunogen: Raised against a recombinant protein corresponding to amino acids 2 to 160 of human MD-2

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: -20 °C

Storage Comment: Can be stored at -20 °C, stable for one year.

Expiry Date: 12 months

Target Details for LY96

Target: LY96 (Lymphocyte Antigen 96 (LY96))

Alternative Name: MD-2 (LY96 Products)

Synonyms: MD2 antibody, ESOP-1 antibody, MD-2 antibody, ly-96 antibody, Ly-96 antibody, Md2 antibody, lymphocyte antigen 96 antibody, LY96 antibody, Ly96 antibody

Background: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs).TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses.TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS.Theof this response is determined by the species of MD-2, e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
Synonyms: MD-2 (1A2E3).Lymphocyte antigen 96 precursor, ESOP-1

NCBI Accession: NP_056179

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades