MTBP antibody (AA 122-139)

Catalog No. ABIN1886842

Product Details anti-MTBP Antibody

Target: MTBP (MDM2 Binding Protein (MTBP))

Binding Specificity: AA 122-139

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTBP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: Affinity chromatography purified via peptide column

Immunogen: Synthetic peptide corresponding to amino acids 122 to 139 of human MTBP, which differ from the mouse sequence by three amino acids.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for MTBP

Target: MTBP (MDM2 Binding Protein (MTBP))

Alternative Name: MTBP (MTBP Products)

Synonyms: MDM2BP antibody, AI429604 antibody, MDM2 binding protein antibody, Mdm2, transformed 3T3 cell double minute p53 binding protein antibody, MTBP antibody, Mtbp antibody

Background: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death.Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2 and MTBP, were recently discovered.The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation.P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein.MDM2 inhibits both p53 mediated G1 arrest and apoptosis.A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53.MTBP is expressed in a variety of normal tissues.
Synonyms: MTBP

Molecular Weight: 104 kDa

NCBI Accession: NP_071328