Caspase 10 antibody (AA 505-521)

Catalog No. ABIN1886883

Product Details anti-Caspase 10 Antibody

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Binding Specificity: AA 505-521

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Antibody only recognizes FLICE2 form of caspase-10.

Purification: Purified by DEAE column

Immunogen: Peptide corresponding to amino acids 505 to 521 of human FLICE2.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for Caspase 10

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Alternative Name: Caspase-10 (CASP10 Products)

Synonyms: xCaspase-10 antibody, alps2 antibody, caspace-10 antibody, caspase-10 antibody, flice2 antibody, mch4 antibody, xCaspace-10 antibody, ALPS2 antibody, FLICE2 antibody, MCH4 antibody, caspase 10 S homeolog antibody, caspase 10 antibody, caspase-10 antibody, casp10.S antibody, casp10 antibody, CASP10 antibody, Casp10 antibody, LOC100848685 antibody

Background: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family.A novel ICE/CED-3 protease was identified recently, designated FLICE2 and Mch4 and renamed as caspase-10.Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors.Caspase-10 is therefore involved in the CD95 and TNFR1 induced apoptosis.Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8 and -9, which causes the proteolytic cleavage of many key proteins such as PARP.Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death.Caspase-10 is expressed in many tissues and cell lines.
Synonyms: Casp-10, FLICE2

Pathways: Apoptosis, Caspase Cascade in Apoptosis