SP110 antibody (C-Term)

Catalog No. ABIN1887079

Product Details anti-SP110 Antibody

Target: SP110 (SP110 Nuclear Body Protein (SP110))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SP110 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide near the carboxy terminus of the human IPR1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SP110

Target: SP110 (SP110 Nuclear Body Protein (SP110))

Alternative Name: IPR1 (SP110 Products)

Synonyms: SP110 antibody, IFI41 antibody, IFI75 antibody, IPR1 antibody, VODI antibody, 5031415C07Rik antibody, 52kDa antibody, 5830484A20Rik antibody, ENSMUSG00000075603 antibody, Ifi75 antibody, Ipr1 antibody, SP110 nuclear body protein antibody, Sp110 nuclear body protein antibody, SP110 antibody, Sp110 antibody

Background: Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene.IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component.The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator.Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.SP110 is the closest homolog of the IPR1 protein in humans.The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis.IPR1/Sp110 is up-regulated after infection with M.tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells.Defects in Sp110 are a cause of severely impaired resistance to infection by M.tuberculosis.
Synonyms: Sp110 nuclear body protein, Intracellular pathogen resistance protein 1

NCBI Accession: NP_004501