Claudin 1 antibody (C-Term)

Catalog No. ABIN1887304

Product Details anti-Claudin 1 Antibody

Target: Claudin 1 (CLDN1)

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 20 amino acid peptide near the carboxy terminus of human CLDN1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for Claudin 1

Target: Claudin 1 (CLDN1)

Alternative Name: CLDN1 (CLDN1 Products)

Synonyms: CLD1 antibody, ILVASC antibody, SEMP1 antibody, AI596271 antibody, cldn19 antibody, claudin-1 antibody, cld1 antibody, ilvasc antibody, semp1 antibody, CLDN1 antibody, claudin 1 antibody, claudin 1 S homeolog antibody, CLDN1 antibody, Cldn1 antibody, cldn1 antibody, cldn1.S antibody

Background: Claudin1 (CLDN1), a member of the claudin family, is an integral membrane protein and a component of tight junction strands.Tight junctions are specialized regions of cell to cell contact consisting of networking strands that act as a molecular gasket for preventing the leakage of ions, water, etc., between cells.They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity.Different tissues exhibit different Claudin composition and CLDN1 expression is often cell type and tissue dependent.Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.CLDN1 and CLDN2 were found to be overexpressed in colonal cancer tissues and may be useful as tumor markers and targets for the treatment of colorectal cancer.Characterization of Claudins expression in human tumors can be an additional diagnostic tool.Recent studies show that CLDN1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3.Along with SCARB1, LDL-R, and the tetraspanin superfamily member CD81, CLDN1 has been reported to be an entry factor for the Hepatitis C virus.
Synonyms: Claudin 1, CLD1, SEMP1, ILVASC, CLDN1

Pathways: Cell-Cell Junction Organization, Hepatitis C