SEC62 antibody (C-Term)

Catalog No. ABIN1887427

Product Details anti-SEC62 Antibody

Target: SEC62 (TLOC1) (Translocation Protein 1 (TLOC1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEC62 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): SEC62 antibody is predicted to not cross-react with other SEC proteins. Multiple isoforms of SEC62 are known to exist.

Purification: Affinity chromatography purified via peptide column

Immunogen: SEC62 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human SEC62.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SEC62

Target: SEC62 (TLOC1) (Translocation Protein 1 (TLOC1))

Alternative Name: SEC62 (TLOC1 Products)

Synonyms: tloc1 antibody, TLOC1 antibody, wu:fb57b06 antibody, zgc:114073 antibody, Dtrp1 antibody, HTP1 antibody, TP-1 antibody, 3100002M17Rik antibody, AI844545 antibody, AW545092 antibody, Tloc1 antibody, Ab2-292 antibody, SEC62 homolog, preprotein translocation factor S homeolog antibody, SEC62 homolog, preprotein translocation factor antibody, membrane unit of ER protein translocation apparatus antibody, SEC62 homolog (S. cerevisiae) antibody, sec62.S antibody, SEC62 antibody, sec62 antibody, Sec62 antibody

Background: SEC62 is an integral membrane protein located in the rough endoplasmic reticulum (ER) and is part of the SEC61-SEC62-SEC63 complex that is the central component of the protein translocation apparatus of the ER membrane.It is speculated that SEC61-SEC62-SEC63 may perform post-translational protein translocation into the ER and might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway.Silencing of this gene with RNAi dramatically reduced the migration and invasive potential of numerous tumor cell lines, suggesting that it may be an attractive target for therapy of various tumors.
Synonyms: Translocation protein 62, HTP1, TP-1, DTRP1, TLOC1

NCBI Accession: NP_003253