IRAK4 antibody (C-Term)

Catalog No. ABIN1887460

Product Details anti-IRAK4 Antibody

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRAK4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Cross-Reactivity (Details): Anti-IRAK-4 has no cross response to other IRAKs.

Purification: Affinity chromatography purified via peptide column

Immunogen: Synthetic peptide corresponding to amino acids at the carboxy terminus of human IRAK-4.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for IRAK4

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Alternative Name: IRAK-4 (IRAK4 Products)

Synonyms: zgc:55553 antibody, IRAK4 antibody, ipd1 antibody, irak-4 antibody, ny-ran-64 antibody, ny-ren-64 antibody, ren64 antibody, irak4 antibody, IPD1 antibody, IRAK-4 antibody, NY-REN-64 antibody, REN64 antibody, 8430405M07Rik antibody, 9330209D03Rik antibody, interleukin 1 receptor associated kinase 4 antibody, interleukin-1 receptor-associated kinase 4 antibody, IRAK4 antibody, irak4 antibody, Irak4 antibody

Background: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR).IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kappaB and MAP kinase (MAPK) by IL-1R/TLR.A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4.Overexpression of IRAK-4 activates NF-kappaB and MAPK pathways.IRAK-4 interacts with and phosphorylates IRAK-1.IRAK-4-deficient animals are completely resistant to the challenge with LPS.Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges.Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.

Molecular Weight: 50 kDa

Pathways: NF-kappaB Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades