FLASH antibody (C-Term)

Catalog No. ABIN1887468

Product Details anti-FLASH Antibody

Target: FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FLASH antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: Affinity chromatography purified via peptide column

Immunogen: Synthetic peptide corresponding to amino acids near the carboxy terminus of human FLASH which differ from those of mouse by one amino acid.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for FLASH

Target: FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))

Alternative Name: FLASH (CASP8AP2 Products)

Synonyms: CASP8AP2 antibody, FLASH antibody, fc74h10 antibody, wu:fc74h10 antibody, zgc:113449 antibody, CED-4 antibody, RIP25 antibody, AA387232 antibody, D4Ertd659e antibody, mKIAA1315 antibody, caspase 8 associated protein 2 antibody, CASP8AP2 antibody, casp8ap2 antibody, Casp8ap2 antibody

Background: A novel mammalian CED-4 homologous was recently identified and cloned in mouse and human and designated FLASH (for FLICE-associated huge protein).FLASH is involved in Fas induced apoptosis.It is recruited to Fas after the receptor cross-linking.Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis.FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8.There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.FLASH is widely expressed.
Synonyms: FLASH

Molecular Weight: 220 kDa

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity