BICD2 antibody (Center)

Catalog No. ABIN1887500

Product Details anti-BICD2 Antibody

Target: BICD2 (Bicaudal D Homolog 2 (BICD2))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BICD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): This BICD2 antibody will not cross-react with BICD1.

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide from near the center of human BICD2.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for BICD2

Target: BICD2 (Bicaudal D Homolog 2 (BICD2))

Alternative Name: BICD2 (BICD2 Products)

Synonyms: SMALED2 antibody, bA526D8.1 antibody, 0610027D24Rik antibody, 1110005D12Rik antibody, AA408834 antibody, mKIAA0699 antibody, MGC84972 antibody, BICD2 antibody, bicd2 antibody, BICD cargo adaptor 2 antibody, bicaudal D homolog 2 (Drosophila) antibody, BICD cargo adaptor 2 L homeolog antibody, zgc:171572 antibody, BICD2 antibody, Bicd2 antibody, bicd2.L antibody, bicd2 antibody, zgc:171572 antibody

Background: BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis.Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin.The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles.Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.
Synonyms: Bicaudal D homolog 2

Pathways: Maintenance of Protein Location