PRTFDC1 antibody (Center)

Catalog No. ABIN1887508

Product Details anti-PRTFDC1 Antibody

Target: PRTFDC1 (phosphoribosyl Transferase Domain Containing 1 (PRTFDC1))

Binding Specificity: Center

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRTFDC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide from near the center of human PRTFDC1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for PRTFDC1

Target: PRTFDC1 (phosphoribosyl Transferase Domain Containing 1 (PRTFDC1))

Alternative Name: PRTFDC1 (PRTFDC1 Products)

Synonyms: HHGP antibody, HPRT antibody, hprt1 antibody, hprt1l antibody, zgc:55561 antibody, zgc:86771 antibody, MGC80959 antibody, OTTMUSG00000011667 antibody, Prtfdc1 antibody, phosphoribosyl transferase domain containing 1 antibody, phosphoribosyl transferase domain containing 1 L homeolog antibody, phosphoribosyltransferase domain containing 1 pseudogene antibody, PRTFDC1 antibody, prtfdc1 antibody, Prtfdc1 antibody, prtfdc1.L antibody, Gm13377 antibody

Background: Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene.Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing.Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth.These results suggest that PRTFDC1 can act as a tumor-suppressor gene.At least three isoforms of PRTFDC1 are known to exist.
Synonyms: Phosphoribosyl transferase domain containing 1, HHGP

NCBI Accession: NP_064585

Pathways: Ribonucleoside Biosynthetic Process