Syntaphilin antibody (Center)
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- Target See all Syntaphilin (SNPH) Antibodies
- Syntaphilin (SNPH)
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Binding Specificity
- Center
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Syntaphilin antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- 16 amino acid peptide from near the center of human Syntaphilin.
- Top Product
- Discover our top product SNPH Primary Antibody
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
- Handling Advice
- Avoid freezing and thawing repeatly.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- Target
- Syntaphilin (SNPH)
- Alternative Name
- Syntaphilin (SNPH Products)
- Synonyms
- bA314N13.5 antibody, 6430515A01 antibody, AW045671 antibody, AW556958 antibody, AW743098 antibody, mKIAA0374 antibody, syntaphilin antibody, SNPH antibody, Snph antibody
- Background
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Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait.Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25.Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis.Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis.Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria.This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function.Multiple isoforms are known to exist.
Synonyms: SNPH - UniProt
- O15079
- Pathways
- Synaptic Vesicle Exocytosis
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