SLPI antibody (Center)

Catalog No. ABIN1887643

Product Details anti-SLPI Antibody

Target: SLPI (Secretory Leukocyte Peptidase Inhibitor (SLPI))

Binding Specificity: Center

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLPI antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide from near the center of human SLPI.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SLPI

Target: SLPI (Secretory Leukocyte Peptidase Inhibitor (SLPI))

Alternative Name: SLPI (SLPI Products)

Synonyms: ALK1 antibody, ALP antibody, BLPI antibody, HUSI antibody, HUSI-I antibody, MPI antibody, WAP4 antibody, WFDC4 antibody, MATN4 antibody, SLPI antibody, ckpi antibody, secretory leukocyte peptidase inhibitor antibody, antileukoproteinase antibody, SLPI antibody, Slpi antibody, LOC102174044 antibody

Background: Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung.SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities.Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1.In peripheral blood monocytes, SLPI can inhibit NF-kappaB activation by inhibiting IkappaB degradation in the cytoplasm and competing for NF-kappaB binding sites in the nucleus.This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.
Synonyms: Secretory leukocyte protease inhibitor, HUSI