CCR8 antibody (Extracellular Loop)

Catalog No. ABIN1887798

Product Details anti-CCR8 Antibody

Target: CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))

Binding Specificity: Extracellular Loop

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids 183 to 201 of human CCR8, which locate in the second extracellular loop.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for CCR8

Target: CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))

Alternative Name: CCR8 (CCR8 Products)

Synonyms: CC-CKR-8 antibody, CCR-8 antibody, CDw198 antibody, CKRL1 antibody, CMKBR8 antibody, CMKBRL2 antibody, CY6 antibody, GPRCY6 antibody, TER1 antibody, C-C antibody, C-C CKR-8 antibody, CKR-8 antibody, Cmkbr8 antibody, mCCR8 antibody, C-C motif chemokine receptor 8 antibody, chemokine (C-C motif) receptor 8 antibody, CCR8 antibody, Ccr8 antibody

Background: CCR8 is one of the chemokine receptors that are required as coreceptors for HIV infection.The genes encoding human and murine CCR8 were cloned and designated TER1, CKR-L1, and ChemR1.The encoded seven transmembrane protein was identified as the receptor for human CC chemokine I-309 and renamed CCR8.Recently, CCR8 was found to serve as a coreceptor for diverse T-cell tropic, dual-tropic and macrophage-tropic HIV-1 strains.CCR8 mediates CC chemokine I-309 induced monocyte chemoattraction and HIV-1 envelope fusion and virus infection, which can be prevented by the CCR8 ligand I-309.CCR8 is expressed in spleen, thymus and T lymphoblastic cell lines.

Molecular Weight: 50 kDa