Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (Middle Region) antibody

Catalog No. ABIN1887809

Product Details

Target: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Binding Specificity: Middle Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Ion exchange chromatography purified

Immunogen: Peptide corresponding to 14 amino acids near the middle of human NADE.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details

Target: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Alternative Name: NADE (NGFRAP1 Products)

Synonyms: BEX3 antibody, Bex antibody, DXS6984E antibody, HGR74 antibody, NADE antibody, NGFRAP1 antibody, LNGFR antibody, Tnfrsf16 antibody, p75 antibody, p75NGFR antibody, p75NTR antibody, AL033356 antibody, Bex3 antibody, DXWsu67e antibody, Gcap27 antibody, Nade antibody, WBP5 antibody, brain expressed X-linked 3 antibody, nerve growth factor receptor (TNFR superfamily, member 16) antibody, BEX3 antibody, Ngfr antibody, Bex3 antibody

Background: The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF).The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR.Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac).Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization.It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed.Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells, NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage.

NCBI Accession: NP_996798

Pathways: Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity