SATB1 antibody (N-Term)

Catalog No. ABIN1888091

Product Details anti-SATB1 Antibody

Target: SATB1 (SATB Homeobox 1 (SATB1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SATB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the amino terminus of the human SATB1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SATB1

Target: SATB1 (SATB Homeobox 1 (SATB1))

Alternative Name: SATB1 (SATB1 Products)

Synonyms: 2610306G12Rik antibody, AW413156 antibody, SATB1 antibody, sb:cb955 antibody, si:ch211-195k18.2 antibody, SATB homeobox 1 antibody, special AT-rich sequence binding protein 1 antibody, SATB homeobox 1a antibody, SATB1 antibody, Satb1 antibody, satb1 antibody, satb1a antibody

Background: Human special AT-rich sequence-binding protein-1 (SATB1) is a nuclear matrix/scaffold-associated region DNA-binding protein, predominantly expressed in the thymus and pre-B cells.Like its homolog SATB2, SATB1 selectively binds double-stranded, special AT-rich DNA sequences in which one strand exclusively consists of well-mixed A, T, and C nucleotides.SATB1 contains a dimerization domain that shares similarity with the PDZ motif, identified as an indispensable element for high-affinity binding of SATB1 to DNA.SATB1 constitutes a functional nuclear architecture that has a 'cage-like' protein distribution surrounding heterochromatin and regulates gene expression through chromatin remodeling/HDAC (histone deacetylase complex) and transcription factors recruitment.SATB1 functions as a 'genome organizer' essential for proper T-cell development.Recent studies show that SATB1 is necessary for breast cancer cells to become metastatic, and when ectopically expressed in non-metastatic cells, can induce invasive activity in vivo.At least two isoforms of SATB1 are known to exist.
Synonyms: DNA-binding protein SATB1, Special AT-rich sequence-binding protein 1

UniProt: Q01826

Pathways: Caspase Cascade in Apoptosis, Activated T Cell Proliferation