PIAS4 antibody (N-Term)

Catalog No. ABIN1888119

Product Details anti-PIAS4 Antibody

Target: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIAS4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the amino terminus of human PIAS4.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for PIAS4

Target: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Alternative Name: PIAS4 (PIAS4 Products)

Synonyms: PIASY antibody, Piasg antibody, ZMIZ6 antibody, pias4 antibody, piasy antibody, wu:fc54c11 antibody, wu:fi18c10 antibody, wu:fi20e09 antibody, wu:fk93f11 antibody, zgc:66410 antibody, piasg antibody, zmiz6 antibody, LOC100219439 antibody, Pias-gamma antibody, pias4l antibody, wu:fi26h11 antibody, zgc:63923 antibody, protein inhibitor of activated STAT 4 antibody, protein inhibitor of activated STAT, 4 antibody, protein inhibitor of activated STAT, 4a antibody, protein inhibitor of activated STAT 4 L homeolog antibody, protein inhibitor of activated STAT, 4b antibody, PIAS4 antibody, Pias4 antibody, pias4a antibody, pias4.L antibody, pias4 antibody, pias4b antibody

Background: The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway.The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS4.The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases.PIAS4 interacts with p53 and blocks its ability to induce Bax and p21 transcription.PIAS4 is also important in the control of the ubiquitin-dependent proteasomal degradation of the Ets-1 transcription factor.PIAS4 has been implicated in the DNA-damage response pathway and is thought to work in combination with PIAS1 for the productive association of 53BP1, BRCA1 and RNF168.
Synonyms: Protein inhibitor of activated STAT protein 4, PIASY, piasg, ZMIZ6

NCBI Accession: NP_056981

Pathways: JAK-STAT Signaling, Interferon-gamma Pathway, Positive Regulation of Response to DNA Damage Stimulus