CNOT4 antibody (N-Term)

Catalog No. ABIN1888129

Product Details anti-CNOT4 Antibody

Target: CNOT4 (CCR4-NOT Transcription Complex Subunit 4 (CNOT4))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNOT4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the amino terminus of the human CNOT4.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for CNOT4

Target: CNOT4 (CCR4-NOT Transcription Complex Subunit 4 (CNOT4))

Alternative Name: CNOT4 (CNOT4 Products)

Synonyms: CLONE243 antibody, NOT4 antibody, NOT4H antibody, Not4 antibody, Not4h antibody, Not4hp antibody, CNOT4 antibody, CCR4-NOT transcription complex subunit 4 antibody, RNA binding (RRM/RBD/RNP motifs) family protein antibody, CCR4-NOT transcription complex, subunit 4 antibody, CCR4-NOT transcription complex subunit 4 L homeolog antibody, CCR4-NOT transcription complex, subunit 4b antibody, CNOT4 antibody, AT3G45630 antibody, Cnot4 antibody, cnot4.L antibody, cnot4b antibody

Background: CNOT4 is a component of the CCR4-NOT transcription complex, a complex that is implicated in the repression of RNA polymerase II transcription.In the CCR4-NOT complex, CNOT4 acts as an E3 ubiquitin-protein ligase and interacts with a subset of E2 ubiquitin-conjugating enzymes through a unique C4C4 RING domain.This E3 ligase activity was shown to be dependent on the selective and specific interaction with the ubiquitin conjugating enzyme UbcH5B.In yeast, mutations in CNOT4 that prevented its interaction with the UbcH5B homolog UBC4 caused increased sensitivity to hydroxyurea, heat shock, and hygromycin B, suggesting that CNOT4 and UbcH5B are involved in stress response in vivo.Multiple isoforms of CNOT4 are known to exist.
Synonyms: CCR4-NOT transcription complex subunit 4, NOT4, NOT4H

NCBI Accession: NP_037448