DEDD2 antibody (N-Term)

Catalog No. ABIN1888176

Product Details anti-DEDD2 Antibody

Target: DEDD2 (Death Effector Domain Containing 2 (DEDD2))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DEDD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Immunoaffinity chromatography purified IgG

Immunogen: Peptide corresponding to 11 amino acids near the amino-terminus of human DEDD2.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for DEDD2

Target: DEDD2 (Death Effector Domain Containing 2 (DEDD2))

Alternative Name: DEDD2 (DEDD2 Products)

Synonyms: FLAME-3 antibody, MGC145883 antibody, 2410050E11Rik antibody, DEDD2 antibody, death effector domain containing 2 antibody, death effector domain containing 2 L homeolog antibody, death effector domain-containing DNA binding protein 2 antibody, DEDD2 antibody, dedd2.L antibody, dedd2 antibody, Dedd2 antibody

Background: Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain.A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified and its over-expression in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD.More recently, work has shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD.Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis.At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
Synonyms: DNA-binding death effector domain-containing protein 2, FLAME-3

NCBI Accession: NP_579874