TNFSF15 antibody (N-Term)

Catalog No. ABIN1888179

Product Details anti-TNFSF15 Antibody

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFSF15 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): This polyclonal antibody will not cross-react with TL1.

Purification: Ion exchange chromatography purified

Immunogen: Peptide corresponding to 14 amino acids near the N terminus of human TL1A.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for TNFSF15

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Alternative Name: TL1A (TNFSF15 Products)

Synonyms: TTPAL antibody, TL1 antibody, TL1A antibody, VEGI antibody, VEGI192A antibody, Tl1 antibody, Tl1a antibody, Vegi antibody, tumor necrosis factor superfamily member 15 antibody, TNF superfamily member 15 antibody, tumor necrosis factor (ligand) superfamily, member 15 antibody, TNFSF15 antibody, Tnfsf15 antibody

Background: Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis.DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) is preferentially expressed by T lymphocytes and upregulated during T cell activation.The ligand for DR3 was recently identified and designated TL1A.TL1A also binds decoy receptor DcR3/TR6, which is expressed in several lung and colon carcinomas and in some normal tissues.TL1A induces apoptosis and NF-kappaB activation in DR3 expressing cells, which is antagonized by DcR3.TL1A is upregulated by proinflammatory cytokines TNF and IL-1.TL1A is a longer variant of TL1 (also called VEGI).
Synonyms: TL1A

Pathways: Positive Regulation of Endopeptidase Activity, Autophagy