MBP antibody

Catalog No. ABIN3071582

Product Details anti-MBP Antibody

Target: MBP (Myelin Basic Protein (MBP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MBP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purpose: Anti-Myelin Basic Protein Mouse Monoclonal Antibody

Specificity: This antibody reacts with residues 130-136 in human myelin basic protein (21.5 kDa and 18.5 kDa molecular forms). It also recognizes primate, rabbit, sheep, goat, rat, and mouse myelin basic protein.

Cross-Reactivity: Goat, Human, Mouse, Primate, Rabbit, Rat, Sheep

Immunogen: Purified human myelin basic protein.

Clone: MBP101

Isotype: IgG2b

Application Details

Application Notes: This antibody may be used in ELISA, immunohistochemistry, and Western blot procedures for detection and/or quantitation of myelin basic protein.ELISA: Human myelin basic protein coated on ELISA wells at 5 μg/mL, binding detected with HRP-conjugated goat anti-mouse IgG + ABTS substrate.

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: Lot specific

Buffer: PBS, pH 7.4

Storage: -20 °C,-80 °C

Storage Comment: This antibody is stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Target Details for MBP

Target: MBP (Myelin Basic Protein (MBP))

Alternative Name: Myelin Basic Protein (MBP Products)

Synonyms: C76307 antibody, Hmbpr antibody, R75289 antibody, golli-mbp antibody, mld antibody, shi antibody, Mbps antibody, cb274 antibody, fj33b11 antibody, mbp antibody, wu:fj33b11 antibody, wu:fq15b02 antibody, zgc:136630 antibody, MGC115135 antibody, myelin basic protein antibody, myelin basic protein a antibody, myelin basic protein L homeolog antibody, MBP antibody, Mbp antibody, mbpa antibody, mbp antibody, mbp.L antibody

Background: Myelin basic protein,The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {PubMed:8544862}.,Myelin membrane, Peripheral membrane protein, Cytoplasmic side. Note=Cytoplasmic side of myelin., [Isoform 3]: Nucleus,MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein

UniProt: P02686