STAT6 antibody (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced) (pTyr641)

Details for Product anti-STAT6 Antibody No. ABIN196700, Supplier: Log in to see
Antigen
  • D12S1644
  • IL-4-STAT
  • STAT6B
  • STAT6C
  • signal transducer and activator of transcription 6, interleukin-4 induced
  • signal transducer and activator of transcription 6
  • signal transducer and activator of transcription 6-like
  • STAT6
  • Stat6
  • LOC100859543
Alternatives
anti-Human STAT6 antibody for Immunoprecipitation
Epitope
pTyr641
90
41
19
17
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15
12
11
6
6
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5
5
5
5
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4
4
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3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
427
188
132
24
20
17
15
14
9
6
3
2
1
1
1
Host
Rabbit
284
169
6
1
1
Clonality
Polyclonal
Conjugate
This STAT6 antibody is un-conjugated
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2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
337
148
135
66
52
44
40
39
34
11
5
4
3
3
2
1
1
1
1
1
1
Options
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human STAT6 around the phosphorylation site of Tyrosine 641 (R-G-YP-V-P).
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. STAT6 (phospho-Tyr641) antibody detects endogenous levels of STAT6 only when phosphorylated at tyrosine 641.
Purification Immunoaffinity chromatography.
Alternative Name STAT6 (STAT6 Antibody Abstract)
Background Synonyms: IL-4 Stat, Signal transducer and activator of transcription 6
Gene ID 6778
NCBI Accession NP_001171549
UniProt P42226
Research Area Chromatin and Nuclear Signaling, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Application Notes Suitable for use in Western blot (1: 500approx. 1: 1000) and Immunohistochemistry (1: 50approx. 1: 100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
 image for anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (pTyr641) antibody (ABIN196700) anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (pTyr641) antibody
 image for anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (pTyr641) antibody (ABIN196700) anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (pTyr641) antibody (Image 2)
Background publications Nelms, Keegan, Zamorano, Ryan, Paul: "The IL-4 receptor: signaling mechanisms and biologic functions." in: Annual review of immunology, Vol. 17, pp. 701-38, 1999 (PubMed).

Malabarba, Rui, Deutsch, Chung, Kalthoff, Farrar, Kirken: "Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha." in: The Biochemical journal, Vol. 319 ( Pt 3), pp. 865-72, 1996 (PubMed).

Quelle, Shimoda, Thierfelder, Fischer, Kim, Ruben, Cleveland, Pierce, Keegan, Nelms: "Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis." in: Molecular and cellular biology, Vol. 15, Issue 6, pp. 3336-43, 1995 (PubMed).

Hou, Schindler, Henzel, Ho, Brasseur, McKnight: "An interleukin-4-induced transcription factor: IL-4 Stat." in: Science (New York, N.Y.), Vol. 265, Issue 5179, pp. 1701-6, 1994 (PubMed).

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