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CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa) (pThr41)

Details for Product anti-CTNNB1 Antibody No. ABIN196814, Supplier: Login to see New
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Antigen
Synonyms Jup, LOC100217813, CTNNB1, CTNNB, Bfc, Catnb, Mesc, ctnnb, id:ibd2058, wu:fb73e10, wu:fi81c06, wu:fk25h01, ctnnb1, CHBCAT, MRD19, armadillo, beta-catenin
Alternatives
Epitope
pThr41, pSer45
(106), (25), (21), (20), (20), (16), (14), (14), (12), (8), (7), (7), (7), (6), (6), (6), (6), (5), (5), (5), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(475), (117), (100), (28), (21), (16), (13), (6), (5), (4), (3), (2), (2), (1), (1), (1)
Host
Rabbit
(340), (167), (2), (2)
Clonality
Polyclonal
Conjugate
This CTNNB1 antibody is un-conjugated
(15), (12), (9), (6), (6), (6), (1), (1), (1)
Application
Western Blotting (WB)
(431), (159), (119), (111), (102), (71), (66), (39), (23), (13), (8), (4), (3), (3), (2), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 0.1 mL
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from humanbeta- Catenin around the phosphorylation site of threonine 41/serine 45 (A-T-TP-T-A-P-SP-L-S).
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. β-Catenin (phospho-Thr41/Ser45) antibody detects endogenous levels of β-Catenin only when phosphorylated at threonine 41/serine 45.
Purification Immunoaffinity chromatography.
Alternative Name Catenin beta-1 (CTNNB1 Antibody Abstract)
Background Synonyms: Beta-catenin, CTNNB, CTNNB1
Gene ID 1499
NCBI Accession NP_001091679
UniProt P35222
Research Area Signaling
Pathways WNT Signaling
Application Notes Suitable for use in Western blot (1: 500approx. 1: 1000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
Image no. 1 for anti-CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa) (pThr41) (ABIN196814) anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (pSer45), (pThr41) antibody
Background publications Provost, McCabe, Stern et al.: "Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin." in: Oncogene, Vol. 24, Issue 16, pp. 2667-76, 2005 (PubMed).

Provost, Yamamoto, Lizardi et al.: "Functional correlates of mutations in beta-catenin exon 3 phosphorylation sites." in: The Journal of biological chemistry, Vol. 278, Issue 34, pp. 31781-9, 2003 (PubMed).

Amit, Hatzubai, Birman et al.: "Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway." in: Genes & development, Vol. 16, Issue 9, pp. 1066-76, 2002 (PubMed).

Liu, Li, Semenov et al.: "Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism." in: Cell, Vol. 108, Issue 6, pp. 837-47, 2002 (PubMed).

Catalog No. ABIN196814
$357.50
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