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Details for Product No. ABIN196815

Catenin beta-1 (CTNB1) (pThr41), (pSer45) antibody

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Antigen
Synonyms Bfc, Catnb, Mesc, ctnnb, id:ibd2058, wu:fb73e10, wu:fi81c06, wu:fk25h01, CHBCAT
Epitope
»Alternatives pThr41, pSer45
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN196815
Quantity 50 µg
Price
275.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen The antiserum was produced against synthesized phosphopeptide derived from humanbeta- Catenin around the phosphorylation site of threonine 41/serine 45 (A-T-TP-T-A-P-SP-L-S).
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. beta-Catenin (phospho-Thr41/Ser45) antibody detects endogenous levels of beta-Catenin only when phosphorylated at threonine 41/serine 45.
Purification Immunoaffinity chromatography.
Alternative Name Catenin beta-1
Background Alternate names: Beta-catenin, CTNNB, CTNNB1
Gene ID 1499
NCBI Accession NP_001091679.1
UniProt P35222
Research Area Signaling
Application Notes Suitable for use in Western blot (1: 500~1: 1000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Liu, Li, Semenov et al.: "Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism." in: Cell, Vol. 108, Issue 6, pp. 837-47, 2002 (PubMed).

Amit, Hatzubai, Birman et al.: "Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway." in: Genes & development, Vol. 16, Issue 9, pp. 1066-76, 2002 (PubMed).

Provost, Yamamoto, Lizardi et al.: "Functional correlates of mutations in beta-catenin exon 3 phosphorylation sites." in: The Journal of biological chemistry, Vol. 278, Issue 34, pp. 31781-9, 2003 (PubMed).

Provost, McCabe, Stern et al.: "Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin." in: Oncogene, Vol. 24, Issue 16, pp. 2667-76, 2005 (PubMed).

Alternatives for antigen "Catenin beta-1 (CTNB1)", type "Antibodies"
Hosts (461), (148), (2), (1)
Reactivities (573), (323), (305), (192), (161), (117), (14), (8), (6), (6), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Applications (446), (173), (151), (140), (117), (96), (71), (55), (40), (22), (8), (5), (3), (1), (1), (1), (1)
Conjugates (19), (16), (16), (15), (14), (14), (14), (14), (14), (14), (14), (1), (1)
Epitopes (55), (53), (49), (42), (42), (28), (20), (16), (15), (15), (13), (12), (9), (7), (7), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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