Amyloid beta (A4) Precursor Protein (APP) (pThr668) antibody

Details for Product No. ABIN196928
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Antigen
Synonyms
APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Abpp, Adap, ... show more
APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10, wu:fk65e12, zgc:85740 show less
Epitope
pThr668
(100), (91), (33), (32), (26), (13), (13), (11), (10), (9), (9), (8), (7), (7), (7), (6), (5), (5), (5), (5), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(700), (322), (287), (176), (168), (161), (153), (50), (13), (13), (4), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(501), (193), (34), (6), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(28), (25), (23), (15), (15), (15), (15), (15), (15), (15), (15), (7), (5), (5), (2), (2)
Application
Western Blotting (WB)
(504), (237), (191), (164), (149), (71), (68), (42), (31), (28), (24), (17), (7), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN196928
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human APP around the phosphorylation site of threonine 668 (A-V-Tp-P-E).
Specificity The antibody detects endogenous levels of APP only when phosphorylated at Threonine 668.
Purification Immunoaffinity Chromatography using epitope-specific phosphopeptide. Non-phosphopeptide antibodies was removed by chromatogramphy using non-phosphopeptide.
Alternative Name Amyloid beta A4 Protein / APP
Background Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver, ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
Gene ID 351
NCBI Accession NP_000475
UniProt P05067
Research Area Neurology, Alzheimer's Disease
Application Notes Suitable for use in Suitable for use in Western blot (1/500-1/1000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
anti-Amyloid beta (A4) Precursor Protein (APP) (pThr668) antibody anti-Amyloid beta (A4) Precursor Protein (APP) (pThr668) antibody
Background publications Suzuki, Oishi, Marshak et al.: "Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein." in: The EMBO journal, Vol. 13, Issue 5, pp. 1114-22, 1994 (PubMed).

Hung, Selkoe: "Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein." in: The EMBO journal, Vol. 13, Issue 3, pp. 534-42, 1994 (PubMed).

Eng, Lund, Campenot: "Synthesis of beta-tubulin, actin, and other proteins in axons of sympathetic neurons in compartmented cultures." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 1, pp. 1-9, 1999 (PubMed).

Iijima, Ando, Takeda et al.: "Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5." in: Journal of neurochemistry, Vol. 75, Issue 3, pp. 1085-91, 2000 (PubMed).

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