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Details for Product No. ABIN197275

Catenin beta-1 (CTNB1) (Thr41), (Ser45) antibody

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Antigen
Synonyms Bfc, Catnb, Mesc, ctnnb, id:ibd2058, wu:fb73e10, wu:fi81c06, wu:fk25h01, CHBCAT
Epitope
»Alternatives Thr41, Ser45
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN197275
Quantity 50 µg
Price
242.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthesized non-phosphopeptide derived from human beta-Catenin around the phosphorylation site of threonine 41/serine 45 A-T-T(p)-T-A-P-S(p)-L-S
Specificity This antibody detects endogenous levels of total beta-Catenin protein.
Purification Affinity-chromatography using epitope-specific immunogen
Alternative Name Catenin beta-1
Background Alternate names: Beta-catenin, CTNNB, CTNNB1
Gene ID 1499
NCBI Accession NP_001091679.1
UniProt P35222
Research Area Signaling
Application Notes Western blot (1: 500~1: 1000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Liu, Li, Semenov et al.: "Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism." in: Cell, Vol. 108, Issue 6, pp. 837-47, 2002 (PubMed).

Amit, Hatzubai, Birman et al.: "Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway." in: Genes & development, Vol. 16, Issue 9, pp. 1066-76, 2002 (PubMed).

Sakanaka: "Phosphorylation and regulation of beta-catenin by casein kinase I epsilon." in: Journal of biochemistry, Vol. 132, Issue 5, pp. 697-703, 2002 (PubMed).

Provost, Yamamoto, Lizardi et al.: "Functional correlates of mutations in beta-catenin exon 3 phosphorylation sites." in: The Journal of biological chemistry, Vol. 278, Issue 34, pp. 31781-9, 2003 (PubMed).

Provost, McCabe, Stern et al.: "Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin." in: Oncogene, Vol. 24, Issue 16, pp. 2667-76, 2005 (PubMed).

Alternatives for antigen "Catenin beta-1 (CTNB1)", type "Antibodies"
Hosts (461), (148), (2), (1)
Reactivities (573), (323), (304), (192), (161), (117), (14), (8), (6), (6), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Applications (446), (173), (151), (140), (117), (96), (71), (55), (40), (22), (8), (5), (3), (1), (1), (1), (1)
Conjugates (19), (16), (16), (15), (14), (14), (14), (14), (14), (14), (14), (1), (1)
Epitopes (55), (53), (49), (43), (43), (28), (20), (16), (15), (15), (13), (12), (9), (7), (6), (5), (5), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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