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Histone Deacetylase 2 (HDAC2) (AA 392-396) antibody

Details for Product No. ABIN197336
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Antigen
Synonyms HD2, RPD3, YAF1, D10Wsu179e, Yy1bp, mRPD3, HISTONE DEACETYLASE, T1N24.9, T1N24_9, histone deacetylase 2
Epitope
AA 392-396
(43), (35), (8), (8), (5), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(153), (89), (86), (27), (26), (24), (17), (3), (2), (2), (2)
Host
Rabbit
(150), (6), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(134), (47), (44), (40), (38), (20), (20), (15), (11), (6), (2), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN197336
308.00 $
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Immunogen Peptide sequence around amino acids 392~396 (E-D-S-G-D) derived from Human HDAC2.
Specificity This antibody detects endogenous levels of total HDAC2 protein.
Purification Affinity Chromatography using epitope-specific immunogen.
Alternative Name HDAC2
Background Histone deacetylase 2 (HDAC2), or transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely to be involved in regulating chromatin structure during transcription. It has been implicated to associate with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. This process is highly conserved from yeast to human.
Alternate names: HD2, Histone deacetylase 2
Gene ID 3066
NCBI Accession NP_001518.3
UniProt Q92769
Research Area Cardiovascular, Hypertrophy, Wnt, DNA/RNA, Transcription Factors
Application Notes Western blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, containing 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Supplier Images
anti-Histone Deacetylase 2 (HDAC2) (AA 392-396) antibody anti-Histone Deacetylase 2 (HDAC2) (AA 392-396) antibody
anti-Histone Deacetylase 2 (HDAC2) (AA 392-396) antibody (2) anti-Histone Deacetylase 2 (HDAC2) (AA 392-396) antibody (Image 2)
anti-Histone Deacetylase 2 (HDAC2) (AA 392-396) antibody (3) anti-Histone Deacetylase 2 (HDAC2) (AA 392-396) antibody (Image 3)
Background publications Marmorstein: "Structure and function of histone acetyltransferases." in: Cellular and molecular life sciences : CMLS, Vol. 58, Issue 5-6, pp. 693-703, 2001 (PubMed).

Tsai, Seto: "Regulation of histone deacetylase 2 by protein kinase CK2." in: The Journal of biological chemistry, Vol. 277, Issue 35, pp. 31826-33, 2002 (PubMed).

Validation Images
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