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Histone Deacetylase 4 (HDAC4) (Ser632) antibody

Details for Product No. ABIN197338
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Antigen
Synonyms
CG1770, DHDAC4, Dmel\\CG1770, GC1770, HDAC, HDAC4a, dHDAC4, dmHDA405, hdac4, dana_GLEANR_19966, DanaGF18710, GF18710, HDAC4, AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, 4932408F19Rik, AI047285, wu ... show more
CG1770, DHDAC4, Dmel\\CG1770, GC1770, HDAC, HDAC4a, dHDAC4, dmHDA405, hdac4, dana_GLEANR_19966, DanaGF18710, GF18710, HDAC4, AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, 4932408F19Rik, AI047285, wu:fa96d08, wu:fc56f08, zgc:152701 show less
Epitope
Ser632
(38), (28), (16), (9), (7), (7), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(182), (95), (75), (31), (24), (24), (1), (1), (1), (1)
Host
Rabbit
(166), (20), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(159), (54), (30), (29), (26), (21), (14), (10), (6), (3), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN197338
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from Human HDAC4 around the phosphorylation site of Serine 632 (A-Q-Sp-S-P).
Specificity This antibody detects endogenous levels of total HDAC4 protein.
Purification Immunoaffinity Chromatography using epitope-specific immunogen.
Alternative Name HDAC4
Background Chromatin is a highly specialized structure composed of tightly compacted chromosomal DNA. Gene expression within the nucleus is controlled, in part, by a host of protein complexes which continuously pack and unpack the chromosomal DNA. One of the known mechanisms of this packing and unpacking process involves the acetylation and deacetylation of the histone proteins comprising the nucleosomal core. Acetylated histone proteins confer accessibility of the DNA template to the transcriptional machinery for expression. Histone deacetylases (HDACs) are chromatin remodeling factors that deacetylate histone proteins and thus, may act as transcriptional repressors. HDACs are classified by their sequence homology to the yeast HDACs and there are currently 2 classes. Class I proteins are related to Rpd3 and members of class II resemble Hda1p. HDAC4 is a class II histone deacetylase containing 1084 amino acid residues. HDAC4 has been shown to interact with NCoR. HDAC4 is a member of the class II mammalian histone deacetylases, which consists of 1084 amino acid residues. Its C terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4, unlike other deacetylases, shuttles between the nucleus and cytoplasm in a process involving active nuclear export. Association of HDAC4 with 14-3-3 results in sequestration of HDAC 4 protein in the cytoplasm. In the nucleus, HDAC4 associates with the myocyte enhancer factor MEF2A. Binding of HDAC4 to MEF2A results in the repression of MEF2A transcriptional activation. HDAC4 has also been shown to interact with other deacetylases such as HDAC3 as well as the corepressors NcoR and SMART.
Alternate names: HD4, Histone deacetylase 4, KIAA0288
Gene ID 9759
NCBI Accession NP_006028.2
UniProt P56524
Research Area Cardiovascular, Hypertrophy, Wnt, DNA/RNA, Transcription Factors
Application Notes Western blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Supplier Images
anti-Histone Deacetylase 4 (HDAC4) (Ser632) antibody anti-Histone Deacetylase 4 (HDAC4) (Ser632) antibody
anti-Histone Deacetylase 4 (HDAC4) (Ser632) antibody (2) anti-Histone Deacetylase 4 (HDAC4) (Ser632) antibody (Image 2)
Background publications Grozinger, Schreiber: "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 14, pp. 7835-40, 2000 (PubMed).

Wang, Kruhlak, Wu et al.: "Regulation of histone deacetylase 4 by binding of 14-3-3 proteins." in: Molecular and cellular biology, Vol. 20, Issue 18, pp. 6904-12, 2000 (PubMed).

Validation Images
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