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DAB1 antibody (Tyr232)
DAB1
Reactivity: Human, Mouse, Rat
IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-DAB1 Antibody
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Target
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DAB1
(Disabled Homolog 1 (Drosophila) (DAB1))
Binding Specificity
All epitopes for DAB1 antibodies
Tyr232
Reactivity
All reactivities for DAB1 antibodies
Human, Mouse, Rat
Host
All hosts for DAB1 antibodies
Rabbit
Clonality
All clonalities for DAB1 antibodies
Polyclonal
Conjugate
All conjugates for DAB1 antibodies
This DAB1 antibody is un-conjugated
Application
All applications for DAB1 antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
Dab1 antibody detects endogenous levels of total Dab1 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Immunogen
The antiserum was produced against synthesized non-phosphopeptide derived from human Dab1around the phosphorylation site of tyrosine 232 (G-V-YP-D-V).
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Application Details
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Application Notes
Immunohistochemistry: 1: 50-1: 100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
PBS (without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Target Details for DAB1
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Target
DAB1
(Disabled Homolog 1 (Drosophila) (DAB1))
Alternative Name
DAB1 (DAB1 Products )
Synonyms
AI956902 antibody, C630028C02Rik antibody, scm antibody, scr antibody, scrambler antibody, yot antibody, disabled-1 antibody, LOC100232823 antibody, si:dkey-242m13.1 antibody, DAB1 antibody, zgc:136547 antibody, DAB1, reelin adaptor protein antibody, disabled 1 antibody, disabled homolog 1 antibody, Dab, reelin signal transducer, homolog 1a (Drosophila) antibody, Dab, reelin signal transducer, homolog 1b (Drosophila) antibody, DAB1 antibody, Dab1 antibody, LOC100232823 antibody, dab1a antibody, dab1b antibody
Background
Disruption of DAB 1 (Disable 1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. DAB1 acts downstream of reelin in a signalling pathway.Synonyms: Disabled homolog 1
Gene ID
1600
NCBI Accession
NP_066566
UniProt
O75553
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