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KRT18 antibody (Keratin 18) (AA 31-35)

Details for Product anti-KRT18 Antibody No. ABIN197580, Supplier: Log in to see
Antigen
  • cb83
  • CK18
  • CYK18
  • dapk1
  • DreK18
  • K18
  • Krt1-18
  • krt18
  • KRT18
  • krtt1c6
  • MGC64569
  • MGC75922
  • sb:cb83
  • wu:fa13f02
  • wu:fb36b04
  • zgc:66015
Alternatives
anti-Human KRT18 antibody for Immunohistochemistry (Frozen Sections)
Epitope
AA 31-35
53
31
25
23
21
15
14
9
9
8
8
8
6
6
6
5
5
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
899
169
146
57
55
33
28
25
19
19
18
18
13
13
7
7
7
5
4
3
3
1
1
1
1
Host
Rabbit
664
267
10
10
6
2
Clonality
Polyclonal
Conjugate
This KRT18 antibody is un-conjugated
51
47
21
18
17
17
14
14
14
14
14
14
14
14
14
11
11
8
7
3
3
3
3
3
3
2
2
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
627
448
386
336
307
280
249
190
164
37
18
12
12
9
2
2
1
1
1
Supplier
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Immunogen Peptide Sequenece around amino acids 31~35 (A-A-S-V-Y) derived from Human Keratin 18.
Specificity This antibody detects endogenous levels of total Keratin 18 protein.
Purification Affinity-Chromatography using epitope-specific immunogen.
Alternative Name Cytokeratin 18 (KRT18 Antibody Abstract)
Background Cytokeratin 18 is an acidic keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies that recognize only Cytokeratins 8 and 18.Synonyms: CK18, CYK18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, K18, KRT18, Keratin 18, Keratin type I cytoskeletal 18, Keratin-18
Gene ID 3875
NCBI Accession NP_000215
UniProt P05783
Research Area Signaling, Cytoskeleton, Extracellular Matrix
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes Immunohistochemistry: 1: 50approx. 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
 image for anti-KRT18 antibody (Keratin 18) (AA 31-35) (ABIN197580) anti-Keratin 18 (KRT18) (AA 31-35) antibody
 image for anti-KRT18 antibody (Keratin 18) (AA 31-35) (ABIN197580) anti-Keratin 18 (KRT18) (AA 31-35) antibody (Image 2)
Background publications Ramaekers, Bosman: "The cytoskeleton and disease." in: The Journal of pathology, Vol. 204, Issue 4, pp. 351-4, 2004 (PubMed).

Chang, Goldman: "Intermediate filaments mediate cytoskeletal crosstalk." in: Nature reviews. Molecular cell biology, Vol. 5, Issue 8, pp. 601-13, 2004 (PubMed).

Collin, Moll, Kubicka, Ouhayoun, Franke: "Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation." in: Experimental cell research, Vol. 202, Issue 1, pp. 132-41, 1992 (PubMed).