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Details for Product No. ABIN197580

Keratin 18 (KRT18) (AA 31-35) antibody

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Antigen
Synonyms K18, CK18, Krt1-18, CYK18, cb83, dapk1, DreK18, sb:cb83, wu:fa13f02, wu:fb36b04, krt18, MGC64569, MGC75922, KRT18
Epitope
»Alternatives AA 31-35
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 3 references available
Catalog no. ABIN197580
Quantity 0.1 mg
Price
297.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide Sequenece around amino acids 31~35 (A-A-S-V-Y) derived from Human Keratin 18.
Specificity This antibody detects endogenous levels of total Keratin 18 protein.
Purification Affinity-Chromatography using epitope-specific immunogen.
Alternative Name Cytokeratin 18
Background Cytokeratin 18 is an acidic keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies that recognize only Cytokeratins 8 and 18.
Alternate names: CK18, CYK18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, K18, KRT18, Keratin 18, Keratin type I cytoskeletal 18, Keratin-18
Gene ID 3875
NCBI Accession NP_000215.1
UniProt P05783
Research Area Signaling, Cytoskeleton, Extracellular Matrix
Application Notes Immunohistochemistry: 1: 50~1: 100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Collin, Moll, Kubicka et al.: "Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation." in: Experimental cell research, Vol. 202, Issue 1, pp. 132-41, 1992 (PubMed).

Chang, Goldman: "Intermediate filaments mediate cytoskeletal crosstalk." in: Nature reviews. Molecular cell biology, Vol. 5, Issue 8, pp. 601-13, 2004 (PubMed).

Ramaekers, Bosman: "The cytoskeleton and disease." in: The Journal of pathology, Vol. 204, Issue 4, pp. 351-4, 2004 (PubMed).

Alternatives for antigen "Keratin 18 (KRT18)", type "Antibodies"
Hosts (277), (187), (9), (4), (3)
Reactivities (421), (114), (102), (43), (43), (34), (28), (17), (12), (8), (6), (6), (4), (4), (3), (3), (3), (3), (2), (1)
Applications (320), (226), (152), (113), (110), (104), (77), (64), (63), (50), (34), (8), (3), (1), (1), (1), (1), (1)
Conjugates (39), (29), (6), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1)
Epitopes (26), (18), (17), (12), (12), (9), (5), (5), (5), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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