IL-18 antibody (AA 1-193)

Catalog No. ABIN1992835

Product Details anti-IL-18 Antibody

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Binding Specificity: AA 1-193

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-18 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Interleukin-18 protein (1-193AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IL-18

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Alternative Name: IL18 (IL18 Products)

Synonyms: Igif antibody, Il-18 antibody, IL-18 antibody, IGIF antibody, ChIL-18 antibody, IL-1g antibody, IL1F4 antibody, IL18 antibody, interleukin 18 antibody, Il18 antibody, IL18 antibody

Background:

Background: A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850).

Aliases: Iboctadekin antibody, IFN gamma inducing factor antibody, IFN-gamma-inducing factor antibody, IGIF antibody, IL 1 gamma antibody, IL 18 antibody, IL 1g antibody, IL-1 gamma antibody, IL-18 antibody, IL1 gamma antibody, IL18 antibody, IL18 protein antibody, IL18_HUMAN antibody, IL1F4 antibody, IL1g antibody, IL1gamma antibody, ILIF4 antibody, Interferon gamma inducing factor antibody, Interferon gamma-inducing factor antibody, Interleukin 1 gamma antibody, Interleukin 18 (interferon-gamma-inducing factor) antibody, Interleukin 18 antibody, Interleukin-1 gamma antibody, Interleukin-18 antibody, Interleukin18 antibody, MGC12320 antibody

UniProt: Q14116

Pathways: Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome