CYP1B1 antibody
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- Target See all CYP1B1 Antibodies
- CYP1B1 (Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CYP1B1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of Human CYP1B1
- Isotype
- IgG
- Top Product
- Discover our top product CYP1B1 Primary Antibody
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- Application Notes
- WB:1:500-1:2000, IHC:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Store at -20 °C or -80 °C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid freeze / thaw cycles.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- CYP1B1 (Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1))
- Alternative Name
- CYP1B1 (CYP1B1 Products)
- Synonyms
- CP1B antibody, CYPIB1 antibody, GLC3A antibody, P4501B1 antibody, P4501b1 antibody, CYP1B1 antibody, CYP1B antibody, zgc:136223 antibody, cytochrome P450 family 1 subfamily B member 1 antibody, cytochrome P450, family 1, subfamily b, polypeptide 1 antibody, cytochrome P450, family 1, subfamily B, polypeptide 1 antibody, cytochrome P450 1B1 antibody, CYP1B1 antibody, Cyp1b1 antibody, cyp1b1 antibody, LOC100719054 antibody
- Background
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Background: Cytochrome P450 1B1 (CYP1B1) is a key enzyme involved in the production of potentially carcinogenic estrogen metabolites and the activation of environmental carcinogens and is the predominant member of the CYP1 family expressed in normal breast tissue and breast cancer. Estrogen has been proposed to trigger breast cancer development via an initiating mechanism involving its metabolite, catechol estrogen (CE). CYP1B1 catalyzes the conversion of 17-beta-estradiol to the catechol estrogen metabolites 2-OH-E2 and 4-OH-E2 which have both been postulated to be involved in mammary carcinogenesis. Genetic polymorphisms in CYP1B1 may play an important role in human prostate carcinogenesis as well. Polymorphism of the CYP1B1 gene at codon 432 (Val-->Leu) is associated with a change in catalytic function.
Aliases: Aryl hydrocarbon hydroxylase antibody, CP1B antibody, CP1B1_HUMAN antibody, Cyp1b1 antibody, CYPIB1 antibody, Cytochrome P450 1B1 antibody, Cytochrome P450 family 1 subfamily B polypeptide 1 antibody, Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile) antibody, Flavoprotein linked monooxygenase antibody, GLC3A antibody, Microsomal monooxygenase antibody, P4501B1 antibody, Xenobiotic monooxygenase antibody
- Pathways
- Steroid Hormone Biosynthesis
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