PDGFB antibody

Catalog No. ABIN1994877

Product Details anti-PDGFB Antibody

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDGFB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human, Mouse, Rat

Purification: Affinity purification

Immunogen: Recombinant protein of Human PDGFB

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:2000, IHC:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Store at -20 °C or -80 °C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PDGFB

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Alternative Name: PDGFB (PDGFB Products)

Synonyms: PDGF-2 antibody, PDGF2 antibody, SIS antibody, SSV antibody, c-sis antibody, pdgf2 antibody, sis antibody, si:ch211-79m20.1 antibody, si:dkey-261d11.1 antibody, PDGF-B antibody, Sis antibody, platelet derived growth factor subunit B antibody, platelet-derived growth factor beta polypeptide antibody, platelet derived growth factor subunit B S homeolog antibody, platelet-derived growth factor beta polypeptide a antibody, platelet derived growth factor, B polypeptide antibody, PDGFB antibody, pdgfb.S antibody, pdgfba antibody, Pdgfb antibody

Background:

Background: PDGF-BB is a cystine-linked homodimer PDGF family member with key roles in development, cell proliferation, cell survival, and angiogenesis. PDGF-BB is expressed by vascular endothelium, megakaryocytes and Leydig cells. PDGF-BB targets pericytes, fibroblasts, monocytes and other cell types. PDGF induces fibroblast growth and migration and is a chemoattractant for monocytes and granulocytes. Precursor PDGF-BB is cleaved intracellularly to generate a form that contains a carboxy-terminal stretch that serves to retain PDGF-BB in the extracellular matrix. In a second cleavage event, the carboxy-terminal stretch is removed extracellularly to generate mature PDGF-BB. PDGF-BB binds to PDGFRβ and induces receptor dimerization. Signaling is through the PI3K/Akt, JNK, and PLCγ pathways. PDGF-BB may have a role in some cancer types.

Aliases: Becaplermin antibody, c sis antibody, FLJ12858 antibody, Oncogene SIS antibody, PDGF 2 antibody, PDGF B chain antibody, PDGF Beta antibody, PDGF subunit B antibody, PDGF-2 antibody, PDGF2 antibody, Pdgfb antibody, PDGFB_HUMAN antibody, Platelet derived growth factor 2 antibody, Platelet derived growth factor B chain antibody, Platelet derived growth factor beta antibody, Platelet derived growth factor beta polypeptide (oncogene SIS) antibody, Platelet derived growth factor beta polypeptide (simian sarcoma viral (v sis) oncogene homolog) antibody, Platelet derived growth factor beta polypeptide antibody, Platelet-derived growth factor B chain antibody, Platelet-derived growth factor beta polypeptide antibody, Platelet-derived growth factor subunit B antibody, Proto-oncogene c-Sis antibody, Simian sarcoma viral (v sis) oncogene homolog antibody, SIS antibody, SSV antibody, v sis platelet derived growth factor beta polypeptide antibody

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling