Integrin beta 3 antibody (FITC)
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- Target See all Integrin beta 3 (ITGB3) Antibodies
- Integrin beta 3 (ITGB3)
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Reactivity
- Mouse, Rat
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Host
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Hamster
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Clonality
- Monoclonal
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Conjugate
- This Integrin beta 3 antibody is conjugated to FITC
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Application
- Flow Cytometry (FACS), Immunoprecipitation (IP)
- Specificity
- Recognizes the murine integrin beta 3 subunit (CD61), a 90kD a type I membrane protein, which is expressed primarily on megakaryocytes, platelets, monocytes, macrophages, granulocytes and endothelial cells. CD61 associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) to form the platelet glycoprotein complex IIb/IIIa and the vitronectin receptor (VNR) respectively. The heterodimers formed with CD61 are receptors for a variety of ligands including fibrinogen, fibronectin, von Willebrand's factor (vWF), vitronectin and thrombospondin. Clone HM beta 3-1 is reported to partially inhibit the binding of CD61 to fibronectin. XXX recommend the use of MCA2299EL for this purpose.
- Purification
- Protein G purified
- Immunogen
- Mouse alpha 5 beta 3 protein purified from the mouse hybridoma 2B4.
- Isotype
- IgG
- Top Product
- Discover our top product ITGB3 Primary Antibody
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- Application Notes
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Approved: Flo (1:1 - 1:10), IP
Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. - Comment
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Target Species of Antibody: Mouse
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4, 0.09 % sodium azide, 1 % BSA.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C,-20 °C
- Storage Comment
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- Target
- Integrin beta 3 (ITGB3)
- Alternative Name
- ITGB3 / Integrin Beta 3 / CD61 (ITGB3 Products)
- Synonyms
- BDPLT16 antibody, BDPLT2 antibody, CD61 antibody, GP3A antibody, GPIIIa antibody, GT antibody, INGRB3 antibody, integrin antibody, INTB3 antibody, GPIIIA antibody, cd61 antibody, gp3a antibody, itgb3 antibody, itgb3.2 antibody, itgb3.1 antibody, integrin subunit beta 3 antibody, integrin beta 3 antibody, integrin subunit beta 3 L homeolog antibody, integrin beta 3a antibody, integrin beta 3b antibody, ITGB3 antibody, Itgb3 antibody, itgb3.L antibody, itgb3a antibody, itgb3b antibody
- Background
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Name/Gene ID: ITGB3
Family: Integrin
Synonyms: ITGB3, BDPLT2, CD61 antigen, GT, gp3A, CD61, GPIIIa, Integrin beta-3 - Gene ID
- 3690
- UniProt
- P05106
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
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