D2HGDH antibody (N-Term)

Catalog No. ABIN2156668

Product Details anti-D2HGDH Antibody

Target: D2HGDH (D-2-Hydroxyglutarate Dehydrogenase (D2HGDH))

Binding Specificity: N-Term

Reactivity: Human, Zebrafish (Danio rerio), Mouse, Rat, Rabbit, Dog, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This D2HGDH antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AFERIVPGGV VTDPEALQAP NVDWLRTLRG CSKVLLRPRT SEEVSHILRH

Predicted Reactivity: Cow: 79%, Dog: 92%, Guinea Pig: 85%, Horse: 79%, Human: 100%, Mouse: 86%, Rabbit: 92%, Rat: 93%, Zebrafish: 77%

Characteristics: This is a rabbit polyclonal antibody against D2HGDH. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human D2HGDH

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for D2HGDH

Target: D2HGDH (D-2-Hydroxyglutarate Dehydrogenase (D2HGDH))

Alternative Name: D2HGDH (D2HGDH Products)

Synonyms: AA408776 antibody, AA408778 antibody, AI325464 antibody, RGD1307976 antibody, D2HGD antibody, zgc:158661 antibody, D-2-hydroxyglutarate dehydrogenase antibody, D2hgdh antibody, D2HGDH antibody, d2hgdh antibody

Background: This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.
Alias Symbols: D2HGD
Protein Size: 325

Molecular Weight: 35 kDa

Gene ID: 728294

NCBI Accession: NM_001287249, NP_001274178

UniProt: Q8N465