Sema4a Protein (AA 33-683) (His tag)
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- Target See all Sema4a Proteins
- Sema4a (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 33-683
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Sema4a protein is labelled with His tag.
- Sequence
- AA 33-683
- Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 72.7 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Purity
- >95 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product Sema4a Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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Semaphorin4A and H-ferritin utilize Tim-1 on human oligodendrocytes: A novel neuro-immune axis." in: Glia, Vol. 66, Issue 7, pp. 1317-1330, (2018) (PubMed).
: "Semaphorin 4A enhances lung fibrosis through activation of Akt via PlexinD1 receptor." in: Journal of biosciences, Vol. 40, Issue 5, pp. 855-62, (2015) (PubMed).
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Semaphorin4A and H-ferritin utilize Tim-1 on human oligodendrocytes: A novel neuro-immune axis." in: Glia, Vol. 66, Issue 7, pp. 1317-1330, (2018) (PubMed).
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- Target
- Sema4a (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a))
- Alternative Name
- Semaphorin 4A (Sema4a Products)
- Synonyms
- SEMA4A Protein, CORD10 Protein, RP35 Protein, SEMAB Protein, SEMB Protein, AI132332 Protein, SemB Protein, Semab Protein, semaphorin 4A Protein, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A Protein, SEMA4A Protein, sema4a Protein, Sema4a Protein
- Background
- Semaphorin-4A (SEMA4A) is also known as Semaphorin-B (SEMAB), which belongs to the semaphorin family. SEMA4A contains one Ig-like C2-type (immunoglobulin-like) domain, one PSI domain and one sema domain. SEMA4A is cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. SEMA4A plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. SEMA4A also promotes phosphorylation of TIMD2 and inhibits angiogenesis. SEMA4A promotes axon growth cone collapse and inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
- Molecular Weight
- 72.7 kDa
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