Amphiphysin antibody

Catalog No. ABIN2427850

Product Details anti-Amphiphysin Antibody

Target: Amphiphysin (AMPH)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Amphiphysin antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogen: Recombinant protein of human BIN1

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Amphiphysin

Target: Amphiphysin (AMPH)

Alternative Name: Amphiphysin II (AMPH Products)

Synonyms: Amp antibody, CG8604 antibody, DAMP antibody, Damp antibody, Dmel\\CG8604 antibody, amph antibody, dAmph antibody, damph antibody, AMPH antibody, Amph antibody, GB16263 antibody, AMPH1 antibody, Amph1 antibody, wu:fq25h04 antibody, zgc:73193 antibody, amphiphysin antibody, Amphiphysin antibody, amphiphysin L homeolog antibody, AMPH antibody, Amph antibody, amph antibody, LOC409851 antibody, amph.L antibody, LOC100343468 antibody

Background: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.