FUCA1 antibody

Catalog No. ABIN2459727

Product Details anti-FUCA1 Antibody

Target: FUCA1 (Fucosidase, alpha-L- 1, Tissue (FUCA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FUCA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human FUCA1.

Application Details

Application Notes: FUCA1 antibody can be used for detection of FUCA1 by ELISA at 1:312500. FUCA1 antibody can be used for detection of FUCA1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store FUCA1 antibody at -20 °C.

Target Details for FUCA1

Target: FUCA1 (Fucosidase, alpha-L- 1, Tissue (FUCA1))

Alternative Name: FUCA1 (FUCA1 Products)

Synonyms: FUCA antibody, FUCA1 antibody, 0610006A03Rik antibody, 9530055J05Rik antibody, Afuc antibody, Fuca antibody, fuca antibody, fuca1 antibody, ATFUC1 antibody, F24D13.11 antibody, F24D13_11 antibody, alpha-L-fucosidase 1 antibody, wu:fb02a09 antibody, zgc:101116 antibody, alpha-L-fucosidase 1 antibody, fucosidase, alpha-L- 1, tissue antibody, alpha-L-fucosidase 1 L homeolog antibody, alpha-L-fucosidase 1, tandem duplicate 2 antibody, FUCA1 antibody, Fuca1 antibody, fuca1.L antibody, fuca1 antibody, FUC1 antibody, LOC9317020 antibody, LOC100285202 antibody, fuca1.2 antibody

Background: Alpha-L-fucosidase (EC 3.2.1.51) is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. At least 2 separate polymorphic alpha-L-fucosidases are recognized in man: that in tissues, FUCA1, which is deficient in fucosidosis, and that in plasma, FUCA2. Fucosidosis is an autosomal recessive lysosomal storage disease caused by defective alpha-L-fucosidase with accumulation of fucose in the tissues. Different phenotypes include clinical features such as neurologic deterioration, growth retardation, visceromegaly, and seizures in a severe early form, coarse facial features, angiokeratoma corporis diffusum, spasticity and delayed psychomotor development in a longer surviving form, and an unusual spondylometaphyseoepiphyseal dysplasia in yet another form.

Molecular Weight: 54 kDa

Gene ID: 2517

NCBI Accession: NP_000138

UniProt: P04066

Pathways: Glycosaminoglycan Metabolic Process