VCAM1 antibody

Catalog No. ABIN2629808

Product Details anti-VCAM1 Antibody

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This VCAM1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: Human CD106

Purification: Purified

Immunogen: B-K9 is a mouse monoclonal IgG1 antibody derived by fusion of X63/Ag8.653 mouse myeloma cells with spleen cells from BALB/c mice immunized with activated human umbilical vein endothelial cells.

Type of Immunogen: Cells

Clone: B-K9

Isotype: IgG1

Application Details

Application Notes: Approved: Flo

Usage: CD106 is a 110kD type 1 transmembrane sialoglycoprotein, which is also known as vascular cell adhesion molecule 1 (VCAM-1). The CD106 protein is primarily expressed on activated vascular endothelium but has also been detected on dendritic cell types, macrophages and non-vascular cells in certain tissues. Expression of CD106 is induced by inflammatory stimuli and cytokines. CD106 binds to the integrins CD49d/CD29 (also known as VLA4) and alpha4beta7 and is important in leucocyte-endothelial cell adhesion and signal transduction. The CD106 protein is thought to play a key role in the migration of leucocyte from the blood into tissues, particularly at sites of inflammation. Studies suggest that CD106 may also play a role in the development of rheumatoid arthritis and atherosclerosis.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C, or in small aliquots at -20°C.

Target Details for VCAM1

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Alternative Name: VCAM1 / CD106 (VCAM1 Products)

Synonyms: CD106 antibody, INCAM-100 antibody, Vcam-1 antibody, VCAM1B antibody, fi76d06 antibody, wu:fi76d06 antibody, zgc:158875 antibody, VCAM1 antibody, vascular cell adhesion molecule 1 antibody, vascular cell adhesion molecule 1b antibody, VCAM1 antibody, Vcam1 antibody, vcam1b antibody, VCAM-1 antibody

Background: Name/Gene ID: VCAM1
Family: ICAM

Synonyms: VCAM1, CD106, CD106 antigen, INCAM-100, V-CAM 1, VCAM-1

Gene ID: 7412

Pathways: Carbohydrate Homeostasis