CD69 (CD69) antibody (FITC)

Details for Product No. ABIN263924
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Antigen
Synonyms 5830438K24Rik, AI452015, AIM, VEA, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3
Reactivity
Human
(120), (105), (16), (4)
Host
Mouse
(89), (77), (45)
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
(27), (23), (17), (10), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Flow Cytometry (FACS)
(164), (51), (38), (30), (22), (14), (7), (7), (6), (3), (2), (1)
Pubmed 5 references available
Quantity 100 tests
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN263924
357.50 $
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Immunogen Anti-µ-stimulated human B lymphocytes
Clone FN50
Isotype IgG1
Characteristics Synonyms: GP32/28, Leu-23, MLR-3, EA1, BL-AC/P26, AIM, Early T-cell activation antigen p60, Earlyactivation antigen CD69, Activation inducer molecule, C-type lectin domain family 2member C
Alternative Name CD69
Background CD69 (C-type lectin domain family 2 C, CLEC2C, also known as AIM) is one of the earliestinducible cell surface molecules acquired during leukocyte activation. This glycoproteinserves as a lectin-type receptor in lymphocytes, NK cells and platelets, it is involved inlymphocyte proliferation. CD69 expression is counteracted on T cells in the AIDS stage ofHIV infection, and may be also predictive for clinical response to chemoimmunotherapy.
UniProt Q07108
Research Area CD Antigens, Surface Receptors of Immune Cells, Immunology
Application Notes Flow Cytometry analysis of human blood cells using 20 ml reagent / 100 ml of whole bloodor 10e6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-CD69 (CD69) antibody (FITC) anti-CD69 (CD69) antibody (FITC)
Background publications López-Cabrera, Santis, Fernández-Ruiz et al.: "Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors." in: The Journal of experimental medicine, Vol. 178, Issue 2, pp. 537-47, 1993 (PubMed).

Nielsen, Afzelius, Ersbøll et al.: "Expression of the activation antigen CD69 predicts functionality of in vitro expanded peripheral blood mononuclear cells (PBMC) from healthy donors and HIV-infected patients." in: Clinical and experimental immunology, Vol. 114, Issue 1, pp. 66-72, 1998 (PubMed).

Drbal, Moertelmaier, Holzhauser et al.: "Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement." in: International immunology, Vol. 19, Issue 5, pp. 675-84, 2007 (PubMed).

Pitsios, Dimitrakopoulou, Tsalimalma et al.: "Expression of CD69 on T-cell subsets in HIV-1 disease." in: Scandinavian journal of clinical and laboratory investigation, Vol. 68, Issue 3, pp. 233-41, 2008 (PubMed).

Hrdinka, Dráber, Stepánek et al.: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, 2011 (PubMed).

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