Retinoblastoma 1 antibody (AA 300-380)

Catalog No. ABIN264374

The Mouse Monoclonal anti-Retinoblastoma 1 antibody is suitable to detect Retinoblastoma 1 in samples from Human, Mouse, Rat and Chicken. It has been validated for IP.

Quick Overview for Retinoblastoma 1 antibody (AA 300-380) (ABIN264374)

Target: Retinoblastoma 1 (RB1)

Reactivity: Human, Mouse, Rat, Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This Retinoblastoma 1 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Clone: C36

Product Details anti-Retinoblastoma 1 Antibody

Binding Specificity: AA 300-380

Specificity: Retinoblastoma binds and regulates E2F transcription factors.

Characteristics: Synonyms: Retinoblastoma 1, Rb, p105-Rb, pRb, pp110, OSRC

Purification: From ascites.

Immunogen: Recombinant protein corresponding to amino acids 300 to 380 of the humanretinoblastoma sequence.

Isotype: IgG1

Application Details

Application Notes: Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.08 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Expiry Date: 12 months

Target Details for Retinoblastoma 1

Target: Retinoblastoma 1 (RB1)

Alternative Name: Retinoblastoma-Associated Protein / RB1

Background: Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110

Gene ID: 5925

UniProt: P06400

Pathways: Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy