Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) antibody

Details for Product No. ABIN264408
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Antigen
Synonyms ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5, CASP-8, Mch5, caspase-8, zgc:92075, casp8-A, xCaspase-8, casp8, CASP8
Reactivity
Human
(201), (70), (58), (28), (13), (12), (12), (9), (4), (2), (1), (1)
Host
Mouse
(175), (53), (6), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(201), (84), (50), (48), (31), (30), (15), (15), (11), (10), (4), (3), (2), (2), (2), (2), (1), (1)
Pubmed 4 references available
Catalog no. ABIN264408
Quantity 0.1 mg
Price
324.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
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Immunogen Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman capase-8 protein and mouse myeloma cells. Genename: CASP8
Clone FLICE 3
Isotype IgG
Characteristics Synonyms: CASP-8, CASP8, MCH5, CAP4, ICE-like apoptotic protease 5, MORT1-associated CED-3homolog, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, Apoptotic cysteineprotease, Apoptotic protease Mch-5
Purification Purified
Alternative Name Caspase-8
Background Caspases are key effectors of programmed cell death. They are synthesized as inactiveproenzymes which are activated by cleavage at a specific aspartate residue to form twosubunits. These subunits are normally linked together by a linker which may be involved inthe regulation of the different caspases. Caspase-8 is a key enzyme in the apoptosispathway. Caspase-8 contains two N-terminal region death effector domains which areremoved to activate the enzyme along with cleavage into the two subunits. These subunitsthen for the active protease which is capable of cleaving caspase-3, -6 and -7. Thesecaspases are then capable of cleaving other cellular substrates such as PARP and DFF,which in turn induce apoptosis.
UniProt Q14790
Research Area Apoptosis/Necrosis
Application Notes Western Blot. Positive Control: MCF-7 cell lysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.08% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Expiry Date 12 months
Supplier Images
anti-Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) antibody anti-Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) antibody
Background publications Hu, Vincenz, Ni et al.: "I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis." in: The Journal of biological chemistry, Vol. 272, Issue 28, pp. 17255-7, 1997 (PubMed).

Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Martin, Siegel, Zheng et al.: "Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal." in: The Journal of biological chemistry, Vol. 273, Issue 8, pp. 4345-9, 1998 (PubMed).

Green: "Apoptotic pathways: the roads to ruin." in: Cell, Vol. 94, Issue 6, pp. 695-8, 1998 (PubMed).

Hosts (175), (53), (6), (1)
Reactivities (201), (70), (58), (28), (13), (12), (12), (9), (4), (2), (1), (1)
Applications (201), (84), (50), (48), (31), (30), (15), (15), (11), (10), (4), (3), (2), (2), (2), (2), (1), (1)
Conjugates (9), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (29), (12), (7), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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