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Caspase 7 antibody (Caspase 7, Apoptosis-Related Cysteine Peptidase)

Details for Product anti-CASP7 Antibody No. ABIN264418, Supplier: Log in to see
Antigen
  • AI314680
  • CASP-7
  • CASP7
  • Caspase-7
  • caspase-7
  • caspase7
  • cmh-1
  • CMH-1
  • ICE-IAP3
  • ice-lap3
  • ICE-LAP3
  • LICE2
  • mCASP-7
  • Mch3
  • mch3
  • MCH3
  • MCH3/SCA-2
  • SCA-2
  • xCaspase-7
Alternatives
anti-Human Caspase 7 antibody for Immunoprecipitation
Reactivity
Human
285
109
85
8
7
4
4
3
3
2
1
1
Host
Mouse
203
90
4
Clonality (Clone)
Monoclonal ()
Conjugate
This Caspase 7 antibody is un-conjugated
14
11
9
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Western Blotting (WB)
249
104
84
73
31
20
14
12
8
8
5
4
3
1
Supplier
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Immunogen Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman caspase-7 protein and mouse myeloma cells. Genename: CASP7
Clone MCH3-5
Isotype IgG
Specificity Reacts with Cysteine-requiring Aspartate Protease-7.
Characteristics Synonyms: CASP-7, CASP7, MCH3, CMH-1, ICE-like apoptotic protease 3, Apoptotic protease Mch-3
Purification Purified
Alternative Name Caspase-7 (CASP7 Antibody Abstract)
Background Caspases are key effectors of programmed cell death. Caspase-7 along with caspase 3 and 6 form the group of effector caspases that are responsible for the cleavage of multiple substrates including the cytokeratins, PARP, alpha fodrin, NuMA and others. Caspase-7 is a 303 amino acid protein with high similarity to caspase-3. Caspase-7 occurs in three varient forms. Granzyme B activates pro-caspase-7 to a form which can cleave poly(ADP-ribose) polymerase (PARP) to its signature fragment of ~85 kDa. Also, in vivo caspase-7 appears to be a better substrate for granzyme B than caspase-3. Pro-caspase-7 has been shown to exist as dimers or high order oligomers. Caspase-7 may be an important intracellular effector of granzyme B-mediated apoptosis and cytotoxic T-lymophocyte-induced cell killing in vivo.Synonyms: Apoptotic protease Mch-3, CASP-7, CASP7, CMH-1, ICE-like apoptotic protease 3, MCH3
Gene ID 840
UniProt P55210
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes Western Blot: Detects proenzyme form of human Caspase-7. Positive Control: MCF-7 cell line.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.08 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Caspase 7 antibody (Caspase 7, Apoptosis-Related Cysteine Peptidase) (ABIN264418) anti-Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7) antibody
Background publications Behrensdorf, van de Craen, Knies, Vandenabeele, Clauss: "The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7." in: FEBS letters, Vol. 466, Issue 1, pp. 143-7, 2000 (PubMed).

Chandler, Cohen, MacFarlane: "Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver." in: The Journal of biological chemistry, Vol. 273, Issue 18, pp. 10815-8, 1998 (PubMed).

Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).