PPAP2A antibody
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- Target See all PPAP2A Antibodies
- PPAP2A (Phosphatidic Acid Phosphatase Type 2A (PPAP2A))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PPAP2A antibody is un-conjugated
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Application
- Western Blotting (WB)
- Specificity
- This antibody recognizes Lysophospholipid Phosphatase (LPP) 1/1A.
- Purification
- Purified
- Immunogen
- Synthetic peptide derived from the LPP1 protein.
- Isotype
- IgG
- Top Product
- Discover our top product PPAP2A Primary Antibody
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- Application Notes
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Western Blot: 5-10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- Phosphate buffered saline with 0.08 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- -20 °C
- Storage Comment
- Store the antibody (in aliquots) at -20 °C. Can be shipped at 2-8 °C.
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- Target
- PPAP2A (Phosphatidic Acid Phosphatase Type 2A (PPAP2A))
- Alternative Name
- PPAP2A / LPP1 (PPAP2A Products)
- Synonyms
- PPAP2A antibody, wun antibody, LLP1a antibody, LPP1 antibody, PAP-2a antibody, PAP2 antibody, Hic53 antibody, Hpic53 antibody, LPP-1 antibody, mPAP antibody, PAP2A antibody, PAP2a2 antibody, phospholipid phosphatase 1 antibody, phosphatidic acid phosphatase type 2A antibody, phospholipid phosphatase 1 L homeolog antibody, PLPP1 antibody, plpp1 antibody, Ppap2a antibody, plpp1.L antibody, Plpp1 antibody
- Background
- Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.Synonyms: Lipid phosphate phosphohydrolase 1, PAP2-alpha, PAP2a, Phosphatidate phosphohydrolase type 2a, Phosphatidic acid phosphatase 2a
- Gene ID
- 8611
- NCBI Accession
- NP_003702
- UniProt
- O14494
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway
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