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Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (N-Term) antibody

Details for Product No. ABIN265160, Supplier: Log in to see
Antigen
  • ATAR
  • CD270
  • HVEA
  • HVEM
  • LIGHTR
  • TR2
  • Atar
  • HveA
  • Hvem
  • Tnfrs14
Epitope
N-Term
19
16
10
9
9
9
9
3
3
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
138
21
1
Host
Rabbit
73
53
14
8
4
Clonality
Polyclonal
Conjugate
Un-conjugated
14
12
7
6
4
3
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
102
58
52
30
20
11
11
7
6
2
2
1
1
1
Supplier
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Immunogen A 15 amino acid peptide from near the amino terminus of human TNFRSF14
Isotype IgG
Specificity This antibody detects TNFRSF14. Located in the membrane and widely expressed, with the highest expression in lung, spleen and thymus (6).
Purification Purified
Alternative Name TNFRSF14 / HVEM (TNFRSF14 Antibody Abstract)
Background Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-κB and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.Synonyms: HVEA, Herpesvirus entry mediator A, TR2, Tumor necrosis factor receptor superfamily member 14, Tumor necrosis factor receptor-like 2
Gene ID 8764
NCBI Accession NP_003811
UniProt Q92956
Application Notes Western Blot: 1 - 2 μg/mL. Positive Control: Raji Cell Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline with 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Supplier Images
 image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (N-Term) antibody (ABIN265160) anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (N-Term) antibody
Background publications Watts: "TNF/TNFR family members in costimulation of T cell responses." in: Annual review of immunology, Vol. 23, pp. 23-68, 2005 (PubMed).

Granger, Rickert: "LIGHT-HVEM signaling and the regulation of T cell-mediated immunity." in: Cytokine & growth factor reviews, Vol. 14, Issue 3-4, pp. 289-96, 2003 (PubMed).

Mauri, Ebner, Montgomery et al.: "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator." in: Immunity, Vol. 8, Issue 1, pp. 21-30, 1998 (PubMed).

Marsters, Ayres, Skubatch et al.: "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB ..." in: The Journal of biological chemistry, Vol. 272, Issue 22, pp. 14029-32, 1997 (PubMed).

Montgomery, Warner, Lum et al.: "Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family." in: Cell, Vol. 87, Issue 3, pp. 427-36, 1996 (PubMed).

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