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Integrin beta 3 antibody (Alexa Fluor 488)
ITGB3
Reactivity: Mouse, Rat
FACS
Host: Hamster
Monoclonal
2C9-G2 (HMbeta3-1)
Alexa Fluor 488
Product Details anti-Integrin beta 3 Antibody (Alexa Fluor 488)
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Target
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Integrin beta 3 (ITGB3)
Reactivity
All reactivities for Integrin beta 3 antibodies
Mouse, Rat
Host
All hosts for Integrin beta 3 antibodies
Hamster
Clonality
All clonalities for Integrin beta 3 antibodies
Monoclonal
Conjugate
All conjugates for Integrin beta 3 antibodies
This Integrin beta 3 antibody is conjugated to Alexa Fluor 488
Application
All applications for Integrin beta 3 antibodies
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 488 under optimal conditions.
Clone
2C9-G2 (HMbeta3-1)
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Protect from prolonged exposure to light. Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C
Target Details for Integrin beta 3
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Target
Integrin beta 3 (ITGB3)
Alternative Name
CD61 (ITGB3 Products )
Synonyms
BDPLT16 antibody, BDPLT2 antibody, CD61 antibody, GP3A antibody, GPIIIa antibody, GT antibody, INGRB3 antibody, integrin antibody, INTB3 antibody, GPIIIA antibody, cd61 antibody, gp3a antibody, itgb3 antibody, itgb3.2 antibody, itgb3.1 antibody, integrin subunit beta 3 antibody, integrin beta 3 antibody, integrin subunit beta 3 L homeolog antibody, integrin beta 3a antibody, integrin beta 3b antibody, ITGB3 antibody, Itgb3 antibody, itgb3.L antibody, itgb3a antibody, itgb3b antibody
Background
CD61 is a 110 kD integrin β chain also known as β3 integrin or gpIIIa. It associates with the integrin αv chain (CD51) to form the vitronectin receptor. In addition, CD61 can associate with the integrin αIIb chain (CD41) to form the gpIIb/IIIa complex. CD61 is expressed on platelets, megakaryocytes, endothelium, smooth muscle, a subset of B cells, myeloid cells, osteoclasts, and mast cells. CD61, in conjunction with CD41 or CD51, mediates adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is mediated by the binding of αv/β3 integrin or vitronectin receptor to CD31 (PECAM-1).
Pathways
Regulation of G-Protein Coupled Receptor Protein Signaling , Signaling Events mediated by VEGFR1 and VEGFR2 , Smooth Muscle Cell Migration , Integrin Complex
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