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CD8 alpha antibody (Alexa Fluor 488)
CD8A
Reactivity: Mouse
FACS, IHC, IP, IF, BR
Host: Rat
Monoclonal
53-6-7
Alexa Fluor 488
Product Details anti-CD8 alpha Antibody (Alexa Fluor 488)
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Target
See all CD8 alpha (CD8A) Antibodies
CD8 alpha (CD8A)
(CD8a Molecule (CD8A))
Reactivity
All reactivities for CD8 alpha antibodies
Mouse
Host
All hosts for CD8 alpha antibodies
Rat
Clonality
All clonalities for CD8 alpha antibodies
Monoclonal
Conjugate
All conjugates for CD8 alpha antibodies
This CD8 alpha antibody is conjugated to Alexa Fluor 488
Application
All applications for CD8 alpha antibodies
Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Blocking Reagent (BR)
Purification
The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 488 under optimal conditions.
Clone
53-6-7
Isotype
IgG2a kappa
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Protect from prolonged exposure to light. Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C
Target Details for CD8 alpha
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Target
CD8 alpha (CD8A)
(CD8a Molecule (CD8A))
Alternative Name
CD8a (CD8A Products )
Synonyms
cd8 antibody, LOC100136450 antibody, BB154331 antibody, Ly-2 antibody, Ly-35 antibody, Ly-B antibody, Lyt-2 antibody, zgc:136643 antibody, CD8 antibody, Leu2 antibody, MAL antibody, p32 antibody, RHACD8-4 antibody, CD8a molecule antibody, uncharacterized LOC100125537 antibody, CD8 alpha antibody, CD8 antigen, alpha chain antibody, T-cell surface glycoprotein CD8 alpha chain antibody, Cd8a antibody, LOC100125537 antibody, LOC100136450 antibody, CD8A antibody, cd8a antibody, LOC100126556 antibody
Background
CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.
Pathways
TCR Signaling
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