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Integrin beta 3 antibody (Alexa Fluor 647)
ITGB3
Reactivity: Human
FACS
Host: Mouse
Monoclonal
VI-PL2
Alexa Fluor 647
Product Details anti-Integrin beta 3 Antibody (Alexa Fluor 647)
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Target
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Integrin beta 3 (ITGB3)
Reactivity
All reactivities for Integrin beta 3 antibodies
Human
Host
All hosts for Integrin beta 3 antibodies
Mouse
Clonality
All clonalities for Integrin beta 3 antibodies
Monoclonal
Conjugate
All conjugates for Integrin beta 3 antibodies
This Integrin beta 3 antibody is conjugated to Alexa Fluor 647
Application
All applications for Integrin beta 3 antibodies
Flow Cytometry (FACS)
Cross-Reactivity
Baboon, Rhesus Monkey, Cynomolgus
Purification
The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.
Clone
VI-PL2
Isotype
IgG1 kappa
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Protect from prolonged exposure to light. Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C
Target Details for Integrin beta 3
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Target
Integrin beta 3 (ITGB3)
Alternative Name
CD61 (ITGB3 Products )
Synonyms
BDPLT16 antibody, BDPLT2 antibody, CD61 antibody, GP3A antibody, GPIIIa antibody, GT antibody, INGRB3 antibody, integrin antibody, INTB3 antibody, GPIIIA antibody, cd61 antibody, gp3a antibody, itgb3 antibody, itgb3.2 antibody, itgb3.1 antibody, integrin subunit beta 3 antibody, integrin beta 3 antibody, integrin subunit beta 3 L homeolog antibody, integrin beta 3a antibody, integrin beta 3b antibody, ITGB3 antibody, Itgb3 antibody, itgb3.L antibody, itgb3a antibody, itgb3b antibody
Background
CD61, also known as integrin β3 and glycoprotein IIIa (gpIIIa), is a 90 kD type I integral transmembrane glycoprotein. It is a member of the integrin family, associating with platelet gpIIb (CD41) to form CD41/CD61 complex and with integrin αV (CD51) to form αV/β3 (CD51/CD61) integrin. CD41/CD61 is expressed on platelets and megakaryocytes, and plays a role in platelet activation and aggregation through interaction with fibrinogen, fibronectin, vWF, and other RGD-containing adhesion molecules. CD51/CD61 is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells involved in tumor metastasis, and in adenovirus infection through binding to RGD motif in extracellular matrix proteins.
Pathways
Regulation of G-Protein Coupled Receptor Protein Signaling , Signaling Events mediated by VEGFR1 and VEGFR2 , Smooth Muscle Cell Migration , Integrin Complex
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