DLL4 antibody (APC)

Catalog No. ABIN2658302

Product Details anti-DLL4 Antibody (APC)

Target: DLL4 (delta-Like 4 (DLL4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DLL4 antibody is conjugated to APC

Application: Intracellular Flow Cytometry (ICFC)

Purification: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.

Clone: MHD4-46

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for DLL4

Target: DLL4 (delta-Like 4 (DLL4))

Alternative Name: delta-Like Protein 4 (DLL4 Products)

Synonyms: hdelta2 antibody, Delta4 antibody, si:ch211-244p18.5 antibody, zgc:136596 antibody, delta like canonical Notch ligand 4 antibody, delta-like 4 (Drosophila) antibody, DLL4 antibody, Dll4 antibody, dll4 antibody

Background: Delta-like protein 4 (DLL4) is a type I transmembrane protein whose extracellular domain contains a DSL domain and eight tandem EGF repeats. After binding of its ligands Notch 1 and Notch 4, the extracellular and cytoplasmic domains are cleaved and the cytoplasmic domain is translocated into the nucleus. DLL4 is expressed in the vascular endothelium, neural epithelium, adrenal cortex, spleen, and lymph nodes. It is also highly expressed in some types of bladder, breast, and renal carcinomas. DLL4 is critical in vascular development and homeostasis.

Pathways: Notch Signaling