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ITGA2 antibody (Biotin)
ITGA2
Reactivity: Mouse
FACS, WB, IHC, IP, BR, St
Host: Rat
Monoclonal
DX5
Biotin
Product Details anti-ITGA2 Antibody (Biotin)
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Target
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ITGA2
(Integrin alpha 2 (ITGA2))
Reactivity
All reactivities for ITGA2 antibodies
Mouse
Host
All hosts for ITGA2 antibodies
Rat
Clonality
All clonalities for ITGA2 antibodies
Monoclonal
Conjugate
All conjugates for ITGA2 antibodies
This ITGA2 antibody is conjugated to Biotin
Application
All applications for ITGA2 antibodies
Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Blocking Reagent (BR), Stimulation (St)
Purification
The solution is free of unconjugated biotin.
Clone
DX5
Isotype
IgM kappa
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for ITGA2
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Target
ITGA2
(Integrin alpha 2 (ITGA2))
Alternative Name
CD49b (ITGA2 Products )
Synonyms
BR antibody, CD49B antibody, GPIa antibody, HPA-5 antibody, VLA-2 antibody, VLAA2 antibody, DX5 antibody, integrin subunit alpha 2 antibody, integrin alpha 2 antibody, ITGA2 antibody, Itga2 antibody
Background
DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.
Pathways
CXCR4-mediated Signaling Events , Smooth Muscle Cell Migration , Integrin Complex
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